I've used the MotoFizz exclusively since 2002, first the large, then the medium. I found the large too big, and I tended to pack to much. My first year of long riding I used some kind of Tourmaster, nothing wrong with it, I just think the Fizz is more versatile and rode better on the seat.
You asked specifically about the Fizz, so I'll keep to the original post. The Fizz has alot of pockets and compartments, outside and in. I use all of them. It also has this shoe bag thing sewed in the flap that I use to carry soiled clothes. Another great feature is the web straps on the flap. I use it to carry stuff like a sweatshirt that I want easy access to, or it can be used to dry my shower towel while goin down the road. Also a good place to carry a road atlas.
The Fizz also gives you the ability to pull stuff out without unloading the bag, it does that with zippers at each end. I'd never buy a bag without that feature, because during the day I find myself adding or taking out of the bag a couple of times.
It has other straps you can use to secure a sleeping pad or bag. I'd shy away from that because of the potential to get that stuff wet in good rain.
I have pics of both (large and small) bags on my web site, in action on the RT and ST. But you'll have to check for them. Too lazy to post the pics here (ballgame on). Just check the trip journals, any trip before 2006 you'll see the large in use, I went to the medium bag in 2007?
Also check the tips section of the web site and look for luggage and packing link, I know for sure you'll see a pic of the RT loaded for a cross country ride. I also get into specfics in what I pack in the Fizz.