I have had both footrest brackets off at the same time, without issue. Well - the seat subframe tries to drop a little - there are inly two bolts holding it, but depending how much fuel is in the lower tank, there is not a great deal of weight on it, and it is easy to find a way to support it either from above or from below.
I have never removed the silencers from my ST1300. The reason being exactly what
@Andrew Shadow describes. This was a common occurrence with my ST1100 with the need to replace them every 35,000 miles. They just rotted away riding ever day through winter on uk roads. It is extremely difficult (but possible) to put the silencer back into the collector without the end digging into the soft side of an old gasket - which is made largely of a wire wool. Once it has dug in, you are stuffed basically. you will never get the pipe past the wrinkle in the gasket. It needs a new one.
For most jobs, the silencer will rotate out of the way quite easily, and rest on a mat on the ground. It needs support if the bike is on the ramp. The silencer will usually need re-seating in the collector to ensure the mounting holes align. Support it near to the collector and rotate the silencer a little, back and forth, while pressing the pipe back into the collector.
But just in case I need to remove the silencer completely, I always keep spare new gaskets. My success rate at getting the silencer back into the old gasket of the 1100 was very low. I found it easier to install a new gasket if I put it onto the silencer first. A cleaned up inside of the collector pipe and a water based lubricant can help. Grease works but it smokes alarmingly when the engine is first fired up.