As far as rejetting is concerned, I'd say read your plugs. They'll tell you what you need to know.
I stopped using K&Ns because I didn't care for the cleaning/oiling drill. I used them on my 750-4 K4, four small filters replacing the OEM and air box. The bike ran rich in the upper mid-range and top end. I read the plugs by maintaining speed for a mile or two, killing the engine and coasting to a stop with clutch in or in neutral. This gave me a better idea of what the plugs looked like at the time of a given throttle opening, not after motoring to a stop.
I raised the needles less than one notch (one notch was too much) and went up two sizes on the high-speed jet, as it was near-white, too lean for my taste. Much improved performance, much less milage at WOT, but a lot of fun to ride. And the sound of unsilenced air filters!
With EFI, I'd think that there is a range of compensation, how wide, I don't know. Your plugs should tell you what you need to know.